Ontology highlight
ABSTRACT:
SUBMITTER: van Kasteren SI
PROVIDER: S-EPMC3220280 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
van Kasteren Sander I SI Berlin Ilana I Colbert Jeff D JD Keane Doreen D Ovaa Huib H Watts Colin C
ACS chemical biology 20110919 11
Proteases constitute a major class of drug targets. Endosomal compartments harbor several protease families whose attenuation may be beneficial to a number of biological processes, including inflammation, cancer metastasis, antigen presentation, and parasite clearance. As a step toward the goal of generalized but targeted protease inhibition in the endocytic pathway, we describe here the synthesis, characterization, and cellular application of a novel multifunctional protease inhibitor. We show ...[more]