Ontology highlight
ABSTRACT:
SUBMITTER: Bolger TA
PROVIDER: S-EPMC3220593 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Bolger Timothy A TA Wente Susan R SR
The Journal of biological chemistry 20110923 46
DEAD-box protein (Dbp) family members are essential for gene expression; however, their precise roles and regulation are not fully defined. During messenger (m)RNA export, Gle1 bound to inositol hexakisphosphate (IP(6)) acts via Dbp5 to facilitate remodeling of mRNA-protein complexes. In contrast, here we define a novel Gle1 role in translation initiation through regulation of a different DEAD-box protein, the initiation factor Ded1. We find that Gle1 physically and genetically interacts with De ...[more]