Ontology highlight
ABSTRACT:
SUBMITTER: Botella H
PROVIDER: S-EPMC3221041 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Cell host & microbe 20110901 3
Mycobacterium tuberculosis thrives within macrophages by residing in phagosomes and preventing them from maturing and fusing with lysosomes. A parallel transcriptional survey of intracellular mycobacteria and their host macrophages revealed signatures of heavy metal poisoning. In particular, mycobacterial genes encoding heavy metal efflux P-type ATPases CtpC, CtpG, and CtpV, and host cell metallothioneins and zinc exporter ZnT1, were induced during infection. Consistent with this pattern of gene ...[more]