Ontology highlight
ABSTRACT:
SUBMITTER: Fatakia SN
PROVIDER: S-EPMC3221663 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Fatakia Sarosh N SN Costanzi Stefano S Chow Carson C CC
PloS one 20111121 11
G protein-coupled receptors (GPCRs) are a superfamily of integral membrane proteins vital for signaling and are important targets for pharmaceutical intervention in humans. Previously, we identified a group of ten amino acid positions (called key positions), within the seven transmembrane domain (7TM) interhelical region, which had high mutual information with each other and many other positions in the 7TM. Here, we estimated the evolutionary selection pressure at those key positions. We found t ...[more]