Ontology highlight
ABSTRACT:
SUBMITTER: Smith MR
PROVIDER: S-EPMC3222788 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Smith Matthew R MR Saad Fred F Egerdie Blair B Sieber Paul P Tammela Teuvo Lj TLj Leder Benjamin Z BZ Ke Chunlei C Goessl Carsten C
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20111201 12
Androgen deprivation therapy (ADT) for prostate cancer increases fracture risk, decreases bone mineral density, and increases bone turnover markers (BTMs) including serum type 1 C-telopeptide (sCTX), tartrate-resistant alkaline phosphatase 5b (TRAP-5b), and procollagen-1 N-terminal telopeptide (P1NP). In a prespecified exploratory analysis of a phase 3, multicenter, double-blind study, we evaluated the effects of denosumab (60 mg subcutaneously every 6 months for 3 years) versus placebo (1468 pa ...[more]