Understanding biomolecular motion, recognition, and allostery by use of conformational ensembles.
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ABSTRACT:
SUBMITTER: Fenwick RB
PROVIDER: S-EPMC3222826 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
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Understanding biomolecular motion, recognition, and allostery by use of conformational ensembles.
Fenwick R Bryn RB Esteban-Martín Santi S Salvatella Xavier X
European biophysics journal : EBJ 20111117 12
We review the role conformational ensembles can play in the analysis of biomolecular dynamics, molecular recognition, and allostery. We introduce currently available methods for generating ensembles of biomolecules and illustrate their application with relevant examples from the literature. We show how, for binding, conformational ensembles provide a way of distinguishing the competing models of induced fit and conformational selection. For allostery we review the classic models and show how con ...[more]
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