Genetic influences on cortical regionalization in the human brain.
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ABSTRACT:
SUBMITTER: Chen CH
PROVIDER: S-EPMC3222857 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
Genetic influences on cortical regionalization in the human brain.
Chen Chi-Hua CH Panizzon Matthew S MS Eyler Lisa T LT Jernigan Terry L TL Thompson Wes W Fennema-Notestine Christine C Jak Amy J AJ Neale Michael C MC Franz Carol E CE Hamza Samar S Lyons Michael J MJ Grant Michael D MD Fischl Bruce B Seidman Larry J LJ Tsuang Ming T MT Kremen William S WS Dale Anders M AM
Neuron 20111101 4
Animal data demonstrate that the development of distinct cortical areas is influenced by genes that exhibit highly regionalized expression patterns. In this paper, we show genetic patterning of cortical surface area derived from MRI data from 406 adult human twins. We mapped genetic correlations of areal expansion between selected seed regions and all other cortical locations, with the selection of seed points based on results from animal studies. "Marching seeds" and a data-driven, hypothesis-f ...[more]
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