Ontology highlight
ABSTRACT:
SUBMITTER: Walbott H
PROVIDER: S-EPMC3222905 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Walbott Hélène H Machado-Pinilla Rosario R Liger Dominique D Blaud Magali M Réty Stéphane S Grozdanov Petar N PN Godin Kate K van Tilbeurgh Herman H Varani Gabriele G Meier U Thomas UT Leulliot Nicolas N
Genes & development 20111101 22
SHQ1 is an essential assembly factor for H/ACA ribonucleoproteins (RNPs) required for ribosome biogenesis, pre-mRNA splicing, and telomere maintenance. SHQ1 binds dyskerin/NAP57, the catalytic subunit of human H/ACA RNPs, and this interaction is modulated by mutations causing X-linked dyskeratosis congenita. We report the crystal structure of the C-terminal domain of yeast SHQ1, Shq1p, and its complex with yeast dyskerin/NAP57, Cbf5p, lacking its catalytic domain. The C-terminal domain of Shq1p ...[more]