Ontology highlight
ABSTRACT:
SUBMITTER: Diaz-Rodriguez E
PROVIDER: S-EPMC3223182 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Díaz-Rodríguez Elena E Álvarez-Fernández Stela S Chen Xi X Paiva Bruno B López-Pérez Ricardo R García-Hernández Juan Luis JL San Miguel Jesús F JF Pandiella Atanasio A
PloS one 20111123 11
Multiple myeloma (MM) is a hematological disease characterized by an abnormal accumulation of plasma cells in the bone marrow. These cells have frequent cytogenetic abnormalities including translocations of the immunoglobulin heavy chain gene and chromosomal gains and losses. In fact, a singular characteristic differentiating MM from other hematological malignancies is the presence of a high degree of aneuploidies. As chromosomal abnormalities can be generated by alterations in the spindle assem ...[more]