Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors.
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ABSTRACT:
SUBMITTER: Walsh SR
PROVIDER: S-EPMC3223417 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
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Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors.
Walsh Stephen R SR Dolin Raphael R
Expert review of vaccines 20110801 8
Less than 200 years after its introduction, widespread use of vaccinia virus (VACV) as a smallpox vaccine has eradicated variola virus. Along with the remarkable success of the vaccination program, frequent and sometimes severe adverse reactions to VACV were encountered. After eradication, VACV has been reserved for select populations who might be at significant risk for orthopoxvirus infections. Events over the past decade have renewed concerns over the potential use of variola virus as a biolo ...[more]
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