Ontology highlight
ABSTRACT:
SUBMITTER: Slavov N
PROVIDER: S-EPMC3223432 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Slavov Nikolai N Macinskas Joanna J Caudy Amy A Botstein David D
Proceedings of the National Academy of Sciences of the United States of America 20111107 47
Despite rapid progress in characterizing the yeast metabolic cycle, its connection to the cell division cycle (CDC) has remained unclear. We discovered that a prototrophic batch culture of budding yeast, growing in a phosphate-limited ethanol medium, synchronizes spontaneously and goes through multiple metabolic cycles, whereas the fraction of cells in the G1/G0 phase of the CDC increases monotonically from 90 to 99%. This demonstrates that metabolic cycling does not require cell division cyclin ...[more]