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Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90.

ABSTRACT: p53 functions as a central node for organizing whether the cell responds to stress with apoptosis or cell cycle arrest; however, the molecular events that lead to apoptotic responses are not completely understood. Here, we identified p90 (also called Coiled-Coil Domain Containing 8) as a unique regulator for p53. p90 has no obvious effects on either the levels of p53 or p53-mediated cell cycle arrest but is specifically required for p53-mediated apoptosis upon DNA damage. Notably, p90 is crucial for Tip60-dependent p53 acetylation at Lys120, therefore facilitating activation of the proapoptotic targets. These studies indicate that p90 is a critical cofactor for p53-mediated apoptosis through promoting Tip60-mediated p53 acetylation.

SUBMITTER: Dai C

PROVIDER: S-EPMC3223437 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90.

Dai Chao C Tang Yi Y Jung Sung Yun SY Qin Jun J Aaronson Stuart A SA Gu Wei W

Proceedings of the National Academy of Sciences of the United States of America 20111114 47

p53 functions as a central node for organizing whether the cell responds to stress with apoptosis or cell cycle arrest; however, the molecular events that lead to apoptotic responses are not completely understood. Here, we identified p90 (also called Coiled-Coil Domain Containing 8) as a unique regulator for p53. p90 has no obvious effects on either the levels of p53 or p53-mediated cell cycle arrest but is specifically required for p53-mediated apoptosis upon DNA damage. Notably, p90 is crucial ...[more]

PMID: 22084066

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