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Chlorinated Withanolides from Withania somnifera.


ABSTRACT: A chlorinated withanolide, 6?-chloro-5?,17?-dihydroxywithaferin A (1), and nine known withanolides, 6?-chloro-5?-hydroxywithaferin A (2), (22R)-5?-formyl-6?,27-dihydroxy-1-oxo-4-norwith-24-enolide, withaferin A, 2,3-dihydrowithaferin A, 3-methoxy-2,3-dihydrowithaferin A, 2,3-didehydrosomnifericin, withanone, withanoside IV and withanoside X, were isolated from Withania somnifera (Solanaceae). All structures were elucidated on the basis of spectroscopic methods (IR, HRESIMS, 1D/2D NMR). X-ray crystallography confirmed the absolute configuration of 1.

SUBMITTER: Tong X 

PROVIDER: S-EPMC3223914 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Chlorinated Withanolides from Withania somnifera.

Tong Xiaoqin X   Zhang Huaping H   Timmermann Barbara N BN  

Phytochemistry letters 20111201 4


A chlorinated withanolide, 6α-chloro-5β,17α-dihydroxywithaferin A (1), and nine known withanolides, 6α-chloro-5β-hydroxywithaferin A (2), (22R)-5β-formyl-6β,27-dihydroxy-1-oxo-4-norwith-24-enolide, withaferin A, 2,3-dihydrowithaferin A, 3-methoxy-2,3-dihydrowithaferin A, 2,3-didehydrosomnifericin, withanone, withanoside IV and withanoside X, were isolated from Withania somnifera (Solanaceae). All structures were elucidated on the basis of spectroscopic methods (IR, HRESIMS, 1D/2D NMR). X-ray cry  ...[more]

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