Ontology highlight
ABSTRACT:
SUBMITTER: Dedman AM
PROVIDER: S-EPMC3224110 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Dedman Alexandra M AM Majeed Yasser Y Tumova Sarka S Zeng Fanning F Kumar Bhaskar B Munsch Christopher C Bateson Alan N AN Wittmann Jürgen J Jäck Hans-Martin HM Porter Karen E KE Beech David J DJ
BMC molecular biology 20110712
<h4>Background</h4>Transient Receptor Potential Canonical 1 (TRPC1) is a widely-expressed mammalian cationic channel with functional effects that include stimulation of cardiovascular remodelling. The initial aim of this study was to investigate variation in TRPC1-encoding gene transcripts.<h4>Results</h4>Extensive TRPC1 transcript alternative splicing was observed, with exons 2, 3 and 5-9 frequently omitted, leading to variants containing premature termination codons. Consistent with the predic ...[more]