Ontology highlight
ABSTRACT:
SUBMITTER: Samuel S
PROVIDER: S-EPMC3224802 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Samuel S S Fan F F Dang L H LH Xia L L Gaur P P Ellis L M LM
Oncogene 20101108 10
Although the effects of vascular endothelial growth factor (VEGF) on angiogenesis and vascular function are well known, the effects of VEGF on tumor cell function remain to be elucidated. We studied phenotypic changes in human colorectal cancer (CRC) cells with homozygous deletion of VEGF alleles to determine the potential direct role of VEGF on tumor cell function. Loss of VEGF expression led to significantly decreased cell growth and increased spontaneous apoptosis in CRC cells (P<0.01). Loss ...[more]