Photoactivated uranyl ion produces single strand breaks in plasmid DNA.
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ABSTRACT:
SUBMITTER: George SA
PROVIDER: S-EPMC3224808 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Publications
Photoactivated uranyl ion produces single strand breaks in plasmid DNA.
George Shannon A SA Whittaker Aaron M AM Stearns Diane M DM
Chemical research in toxicology 20111026 11
Uranium is an important emerging toxicant whose use has outpaced the rate at which we are learning about its health effects. One unexplored pathway for uranium toxicity involves the photoactivation of uranyl ion by UV light to produce U(5+) and oxygen radicals. The purpose of this study was to provide proof of principle data by testing the hypothesis that coexposures of DNA to uranyl acetate and UVB irradiation should produce more DNA strand breaks than individual exposures. Results supported th ...[more]
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