Ontology highlight
ABSTRACT:
SUBMITTER: Linney E
PROVIDER: S-EPMC3224961 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Linney Elwood E Perz-Edwards Alyssa A Kelley Betty B
Gene 20110713 1-2
The retinoic acid receptors (RARs or rars) and the thyroid hormone receptors are members of the steroid receptor superfamily that interact with their DNA response elements (for RARs: retinoic acid response elements or RAREs) in the regulatory regions of promoters in the absence of their ligand. In this ligand minus configuration, it has been suggested that the RAR provides a binding site for a corepressor (SMRT or N-CoR) that also brings in other proteins to repress the gene. In the presence of ...[more]