Ontology highlight
ABSTRACT:
SUBMITTER: Montero A
PROVIDER: S-EPMC3225806 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Montero Ana A Gastaminza Pablo P Law Mansun M Cheng Guofeng G Chisari Francis V FV Ghadiri M Reza MR
Chemistry & biology 20111101 11
Hepatitis C virus (HCV) infects chronically 3% of the world population and the current therapy against this pathogen is only partially effective. With the aim of developing novel antiviral strategies against HCV, we screened a D,L-α-peptide library using an unbiased methodology based on a cell culture infection system for HCV. We found a family of highly active amphiphilic eight-residue cyclic D,L-α-peptides that specifically blocked entry of all tested HCV genotypes into target cells at a postb ...[more]