Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2.
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ABSTRACT:
SUBMITTER: Kinch L
PROVIDER: S-EPMC3226726 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
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Succination of Keap1 and activation of Nrf2-dependent antioxidant pathways in FH-deficient papillary renal cell carcinoma type 2.
Kinch Lisa L Grishin Nick V NV Brugarolas James J
Cancer cell 20111001 4
Fumarate hydratase (FH) is a tumor suppressor, but how it acts is unclear. Two reports in this issue of Cancer Cell reveal that FH deficiency leads to succination of Keap1, stabilization of Nrf2, and induction of stress-response genes including HMOX1, which is important for the survival of FH-deficient cells. ...[more]
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