Ontology highlight
ABSTRACT:
SUBMITTER: Puliaeva I
PROVIDER: S-EPMC3226733 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Puliaeva Irina I Soloviova Kateryna K Puliaiev Maksym M Lang Thomas T Puliaev Roman R Via Charles S CS
Journal of immunology (Baltimore, Md. : 1950) 20101129 1
T cell upregulation of B7 molecules CD80 and CD86 limits T cell expansion in immunodeficient hosts; however, the relative roles of CD80 separate from CD86 on CD4 versus CD8 T cells in a normal immune system are not clear. To address this question, we used the parent-into-F1 (P→F1) murine model of graft-versus-host disease and transferred optimal and suboptimal doses of CD80 and/or CD86 knockout (KO) T cells into normal F1 hosts. Enhanced elimination of host B cells by KO T cells was observed onl ...[more]