Quantitative high-resolution genomic analysis of single cancer cells.
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ABSTRACT:
SUBMITTER: Hannemann J
PROVIDER: S-EPMC3227572 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Quantitative high-resolution genomic analysis of single cancer cells.
Hannemann Juliane J Meyer-Staeckling Sönke S Kemming Dirk D Alpers Iris I Joosse Simon A SA Pospisil Heike H Kurtz Stefan S Görndt Jennifer J Püschel Klaus K Riethdorf Sabine S Pantel Klaus K Brandt Burkhard B
PloS one 20111130 11
During cancer progression, specific genomic aberrations arise that can determine the scope of the disease and can be used as predictive or prognostic markers. The detection of specific gene amplifications or deletions in single blood-borne or disseminated tumour cells that may give rise to the development of metastases is of great clinical interest but technically challenging. In this study, we present a method for quantitative high-resolution genomic analysis of single cells. Cells were isolate ...[more]
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