Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase.
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ABSTRACT:
SUBMITTER: McCarty RM
PROVIDER: S-EPMC3227869 | biostudies-literature | 2009 Mar
REPOSITORIES: biostudies-literature
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Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase.
McCarty Reid M RM Somogyi Arpád A Bandarian Vahe V
Biochemistry 20090301 11
To elucidate the early steps required during biosynthesis of a broad class of 7-deazapurine-containing natural products, we have studied the reaction catalyzed by Escherichia coli QueD, a 6-pyruvoyl-5,6,7,8-tetrahydropterin synthase (PTPS) homologue possibly involved in queuosine biosynthesis. While mammalian PTPS homologues convert 7,8-dihydroneopterin triphosphate (H(2)NTP) to 6-pyruvoyltetrahydropterin (PPH(4)) in biopterin biosynthesis, E. coli QueD catalyzes the conversion of H(2)NTP to 6-c ...[more]
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