High expression of macrophage colony-stimulating factor-1 receptor in peritumoral liver tissue is associated with poor outcome in hepatocellular carcinoma after curative resection.

ABSTRACT:

Background

Macrophage colony-stimulating factor 1 receptor (CSF-1R) expression in hepatocellular carcinoma (HCC) and its prognostic values are unclear. This study evaluated the prognostic values of the intratumoral and peritumoral expression of CSF-1R in HCC patients after curative resection.

Methods

Tissue microarrays containing material from cohort 1 (105 patients) and cohort 2 (32 patients) were constructed. Immunohistochemistry was performed and prognostic values of these and other clinicopathological data were evaluated. The CSF-1R mRNA level was assessed by quantitative real-time polymerase chain reaction in cohort 3 (52 patients).

Results

Both the CSF-1R density and its mRNA level were significantly higher in peritumoral liver tissue than in the corresponding t

SUBMITTER: Jia JB 

PROVIDER: S-EPMC3228006 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature