Unknown

Dataset Information

0

Epstein-barr virus-positive diffuse large B-cell lymphoma of the elderly: what we know so far.


ABSTRACT: Epstein-Barr virus-positive (EBV-positive) diffuse large B-cell lymphoma (DLBCL) of the elderly is a newly described lymphoproliferative disorder recently included as a "provisional" entity in the most current WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. The objective of this review is to provide a thorough and current summary of the existing knowledge of this subtype of DLBCL. We will review and discuss the incidence of EBV expression in DLBCL, the pathogenesis behind EBV-driven malignant transformation of B cells, the different EBV latency patterns associated with DLBCL, the distinct pathologic characteristics of EBV-positive DLBCL, the potential predictive and prognostic value of EBV tumoral status in patients with DLBCL, and potential strategies for the treatment of this rare entity, which is characterized by a suboptimal response to therapy and poor survival rate.

SUBMITTER: Castillo JJ 

PROVIDER: S-EPMC3228047 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

altmetric image

Publications

Epstein-barr virus-positive diffuse large B-cell lymphoma of the elderly: what we know so far.

Castillo Jorge J JJ   Beltran Brady E BE   Miranda Roberto N RN   Paydas Semra S   Winer Eric S ES   Butera James N JN  

The oncologist 20110106 1


Epstein-Barr virus-positive (EBV-positive) diffuse large B-cell lymphoma (DLBCL) of the elderly is a newly described lymphoproliferative disorder recently included as a "provisional" entity in the most current WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. The objective of this review is to provide a thorough and current summary of the existing knowledge of this subtype of DLBCL. We will review and discuss the incidence of EBV expression in DLBCL, the pathogenesis behind E  ...[more]

Similar Datasets

| S-EPMC3301425 | biostudies-literature
| S-EPMC4546442 | biostudies-literature
| S-EPMC10792184 | biostudies-literature
| S-EPMC4511873 | biostudies-other
| S-EPMC6091946 | biostudies-literature
| S-EPMC4317839 | biostudies-literature
| S-EPMC8068359 | biostudies-literature
| S-EPMC10651334 | biostudies-literature
2014-02-01 | E-MTAB-1971 | biostudies-arrayexpress
| S-EPMC5448608 | biostudies-literature