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Solar composition from the Genesis Discovery Mission.

ABSTRACT: Science results from the Genesis Mission illustrate the major advantages of sample return missions. (i) Important results not otherwise obtainable except by analysis in terrestrial laboratories: the isotopic compositions of O, N, and noble gases differ in the Sun from other inner solar system objects. The N isotopic composition is the same as that of Jupiter. Genesis has resolved discrepancies in the noble gas data from solar wind implanted in lunar soils. (ii) The most advanced analytical instruments have been applied to Genesis samples, including some developed specifically for the mission. (iii) The N isotope result has been replicated with four different instruments.

SUBMITTER: Burnett DS

PROVIDER: S-EPMC3228446 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Solar composition from the Genesis Discovery Mission.

Burnett D S DS Team Genesis Science GS

Proceedings of the National Academy of Sciences of the United States of America 20110509 48

Science results from the Genesis Mission illustrate the major advantages of sample return missions. (i) Important results not otherwise obtainable except by analysis in terrestrial laboratories: the isotopic compositions of O, N, and noble gases differ in the Sun from other inner solar system objects. The N isotopic composition is the same as that of Jupiter. Genesis has resolved discrepancies in the noble gas data from solar wind implanted in lunar soils. (ii) The most advanced analytical instr ...[more]

PMID: 21555545

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Project description:Neural retina leucine zipper (NRL) is an essential gene for the fate determination and differentiation of the precursor cells into rod photoreceptors in mammals. Mutations in NRL are associated with the autosomal recessive enhanced S-cone syndrome and autosomal dominant retinitis pigmentosa. However, the exact role of Nrl in regulating the development and maintenance of photoreceptors in the zebrafish (Danio rerio), a popular animal model used for retinal degeneration and regeneration studies, has not been fully determined. In this study, we generated an nrl knockout zebrafish model via the CRISPR-Cas9 technology and observed a surprising phenotype characterized by a reduced number, but not the total loss, of rods and over-growth of green cones. We discovered two waves of rod genesis, nrl-dependent and -independent at the embryonic and post-embryonic stages, respectively, in zebrafish by monitoring the rod development. Through bulk and single-cell RNA sequencing, we characterized the gene expression profiles of the whole retina and each retinal cell type from the wild type and nrl knockout zebrafish. The over-growth of green cones and mis-expression of green-cone-specific genes in rods in nrl mutants suggested that there are rod/green-cone bipotent precursors, whose fate choice between rod versus green-cone is controlled by nrl. Besides, we identified the mafba gene as a novel regulator of the nrl-independent rod development, based on the cell-type-specific expression patterns and the retinal phenotype of nrl/mafba double-knockout zebrafish. Gene collinearity analysis revealed the evolutionary origin of mafba and suggested that the function of mafba in rod development is specific to modern fishes. Furthermore, the altered photoreceptor composition and abnormal gene expression in nrl mutants caused progressive retinal degeneration and subsequent regeneration. Accordingly, this study revealed a novel function of the mafba gene in rod development and established a working model for the developmental and regulatory mechanisms regarding the rod and green-cone photoreceptors in zebrafish.

Dataset Information

Solar composition from the Genesis Discovery Mission.

Publications

Solar composition from the Genesis Discovery Mission.

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