Ontology highlight
ABSTRACT:
SUBMITTER: Tsuji S
PROVIDER: S-EPMC3228499 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Tsuji Shoichiro S Cortesão Catarina C Bram Richard J RJ Platt Jeffrey L JL Cascalho Marilia M
Blood 20111007 22
Deficiencies in transmembrane activator and CAML interactor (TACI) result in common variable immune deficiency, a syndrome marked by recurrent infections with encapsulated microorganisms, impaired production of antibodies, and lymphoproliferation. How TACI promotes antibody production and inhibits lymphoproliferation is not understood. To answer this question, we studied the generation of immunity to protein antigens in both TACI-deficient and TACI-proficient mice. We show that TACI promotes sus ...[more]