Ontology highlight
ABSTRACT:
SUBMITTER: Narasimhan M
PROVIDER: S-EPMC3228534 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Narasimhan Madhusudhanan M Mahimainathan Lenin L Rathinam Mary Latha ML Riar Amanjot Kaur AK Henderson George I GI
Molecular pharmacology 20110826 6
Ethanol (ETOH) can cause apoptotic death of neurons by depleting GSH with an associated increase in oxidative stress. The current study illustrates a means to overcome this ETOH-induced neurotoxicity by enhancing GSH through boosting Nrf2, a transcription factor that controls GSH homeostasis. ETOH treatment caused a significant increase in Nrf2 protein, transcript expression, Nrf2-DNA binding activity, and expression of its transcriptional target, NQO1, in primary cortical neuron (PCNs). However ...[more]