Ontology highlight
ABSTRACT:
SUBMITTER: Topfer K
PROVIDER: S-EPMC3228689 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Journal of biomedicine & biotechnology 20111115
An intact immune system is essential to prevent the development and progression of neoplastic cells in a process termed immune surveillance. During this process the innate and the adaptive immune systems closely cooperate and especially T cells play an important role to detect and eliminate tumor cells. Due to the mechanism of central tolerance the frequency of T cells displaying appropriate arranged tumor-peptide-specific-T-cell receptors is very low and their activation by professional antigen ...[more]