Ontology highlight
ABSTRACT:
SUBMITTER: Cohen JC
PROVIDER: S-EPMC3229276 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Cohen Jonathan C JC Horton Jay D JD Hobbs Helen H HH
Science (New York, N.Y.) 20110601 6037
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects one-third of adults and an increasing number of children in developed countries. The disease begins with the aberrant accumulation of triglyceride in the liver, which in some individuals elicits an inflammatory response that can progress to cirrhosis and liver cancer. Although NAFLD is strongly associated with obesity and insulin resistance, its pathogenesis remains poorly understood, and therapeutic options are ...[more]