Ontology highlight
ABSTRACT:
SUBMITTER: Feng L
PROVIDER: S-EPMC3229422 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Feng Lei L Sun Hui H Zhang Ying Y Li De-Feng DF Wang Da-Cheng DC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100607 10
Thomsen-Friedenreich (TF) antigen, which plays an important role in the regulation of cancer cell proliferation, occurs in ∼90% of all human cancers and precancerous conditions. Although TF antigen has been known for almost 80 yr as a pancarcinoma antigen, the recognition mechanism between TF antigen and target protein has not been structurally characterized. A number of studies indicated that TF disaccharide is a potential ligand of the galactoside-binding galectins. In this work, we identified ...[more]