Modulation of calcium-dependent inactivation of L-type Ca2+ channels via ?-adrenergic signaling in thalamocortical relay neurons.
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ABSTRACT:
SUBMITTER: Rankovic V
PROVIDER: S-EPMC3229489 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
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Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
Rankovic Vladan V Landgraf Peter P Kanyshkova Tatyana T Ehling Petra P Meuth Sven G SG Kreutz Michael R MR Budde Thomas T Munsch Thomas T
PloS one 20111202 12
Neuronal high-voltage-activated (HVA) Ca(2+) channels are rapidly inactivated by a mechanism that is termed Ca(2+)-dependent inactivation (CDI). In this study we have shown that β-adrenergic receptor (βAR) stimulation inhibits CDI in rat thalamocortical (TC) relay neurons. This effect can be blocked by inhibition of cAMP-dependent protein kinase (PKA) with a cell-permeable inhibitor (myristoylated protein kinase inhibitor-(14-22)-amide) or A-kinase anchor protein (AKAP) St-Ht31 inhibitory peptid ...[more]
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