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ABSTRACT:
SUBMITTER: Bamrungsap S
PROVIDER: S-EPMC3229930 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Bamrungsap Suwussa S Shukoor Mohammed Ibrahim MI Chen Tao T Sefah Kwame K Tan Weihong W
Analytical chemistry 20110922 20
Magnetic relaxation switch (MRSw) detection is based on aggregate formation or dissociation when magnetic nanoparticles (MNPs) bind to target molecules. In the aggregated state, the dephasing rate of nearby proton spins is higher than in the dispersed state, resulting in a decrease in the spin-spin relaxation time, T(2). In this work, an MRSw-based nanosensor for lysozyme (Lys) protein detection was achieved using iron oxide nanoparticles conjugated with either Lys aptamer or linker DNA, which c ...[more]