Ontology highlight
ABSTRACT:
SUBMITTER: Chen T
PROVIDER: S-EPMC3229931 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Chen Tao T Shukoor Mohammed Ibrahim MI Wang Ruowen R Zhao Zilong Z Yuan Quan Q Bamrungsap Suwussa S Xiong Xiangling X Tan Weihong W
ACS nano 20110921 10
Targeted chemotherapy and magnetic resonance imaging of cancer cells in vitro has been achieved using a smart multifunctional nanostructure (SMN) constructed from a porous hollow magnetite nanoparticle (PHMNP), a heterobifunctional PEG ligand, and an aptamer. The PHMNPs were prepared through a three-step reaction and loaded with the anticancer drug doxorubicin while being functionalized with PEG ligands. Targeting aptamers were then introduced by reaction with the PEG ligands. The pores of the P ...[more]