Ontology highlight
ABSTRACT:
SUBMITTER: Pidoux G
PROVIDER: S-EPMC3230380 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Pidoux Guillaume G Witczak Oliwia O Jarnæss Elisabeth E Myrvold Linda L Urlaub Henning H Stokka Anne Jorunn AJ Küntziger Thomas T Taskén Kjetil K
The EMBO journal 20111007 21
Adrenergic stimulation of adipocytes yields a cAMP signal that activates protein kinase A (PKA). PKA phosphorylates perilipin, a protein localized on the surface of lipid droplets that serves as a gatekeeper to regulate access of lipases converting stored triglycerides to free fatty acids and glycerol in a phosphorylation-dependent manner. Here, we report a new function for optic atrophy 1 (OPA1), a protein known to regulate mitochondrial dynamics, as a dual-specificity A-kinase anchoring protei ...[more]