Ontology highlight
ABSTRACT:
SUBMITTER: Kotake Y
PROVIDER: S-EPMC3230933 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Kotake Y Y Nakagawa T T Kitagawa K K Suzuki S S Liu N N Kitagawa M M Xiong Y Y
Oncogene 20101213 16
A 42 kb region on human chromosome 9p21 encodes for three distinct tumor suppressors, p16(INK4A), p14(ARF) and p15(INK4B), and is altered in an estimated 30-40% of human tumors. The expression of the INK4A-ARF-INK4B gene cluster is silenced by polycomb during normal cell growth and is activated by oncogenic insults and during aging. How the polycomb is recruited to repress this gene cluster is unclear. Here, we show that expression of oncogenic Ras, which stimulates the expression of p15(INK4B) ...[more]