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Mechanical behavior of fully expanded commercially available endovascular coronary stents.

ABSTRACT: The mechanical behavior of endovascular coronary stents influences their therapeutic efficacy. Through computational studies, researchers can analyze device performance and improve designs. We developed a 1-dimensional finite element method, net-based algorithm and used it to analyze the effects of radial loading and bending in commercially available stents. Our computational study included designs modeled on the Express, Cypher, Xience, and Palmaz stents.We found that stents that did not fully expand were less rigid than the fully expanded stents and, therefore, exhibited larger displacement. Stents with an open-cell design, such as Express-like or Xience-like stents, had a higher bending flexibility. Stents with in-phase circumferential rings, such as the Xience-like stent, had the smallest longitudinal extension when exposed to radial compression forces. Thus, the open-cell model that had in-phase circumferential rings connected by straight horizontal struts exhibited radial stiffness, bending flexibility, and the smallest change in stent length during radial forcing. The Palmaz-like stent was the most rigid of all. These findings are supported by clinical experience.Computer simulations of the mechanical properties of endovascular stents offer sophisticated insights into the mechanical behavior of different stent designs and should be used whenever possible to help physicians decide which stent is best for treating a given lesion. Our 1-dimensional finite element method model is incomparably simpler, faster, and more accurate than the classical 3-dimensional approaches. It can facilitate stent design and may aid in stent selection in the clinical setting.

SUBMITTER: Tambaca J

PROVIDER: S-EPMC3231552 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Mechanical behavior of fully expanded commercially available endovascular coronary stents.

Tambaca Josip J Canic Suncica S Kosor Mate M Fish R David RD Paniagua David D

Texas Heart Institute journal 20110101 5

The mechanical behavior of endovascular coronary stents influences their therapeutic efficacy. Through computational studies, researchers can analyze device performance and improve designs. We developed a 1-dimensional finite element method, net-based algorithm and used it to analyze the effects of radial loading and bending in commercially available stents. Our computational study included designs modeled on the Express, Cypher, Xience, and Palmaz stents.We found that stents that did not fully ...[more]

PMID: 22163122

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Project description:IntroductionThe ability to reliably measure real-world vaping behavior is critical to understand exposures to potential toxins. Commercially available mobile topography devices were originally designed to measure cigarette puffing behavior. Information regarding how applicable these devices are to the measurement of electronic cigarette (e-cigarette) vaping topography is needed.MethodsClinical Research Support System (CReSS; Pocket) and Smoking Puff Analyzer Mobile (SPA-M) topography devices were tested against the calibrated laboratory-based smoking puff analyzer duplicator (SPA-D) device combined with an analytical smoking machine that generates programmable puffs with high precision. Puff topography of e-cigarettes was measured over a range of puff volumes (10-130 mL) at 2 and 5 s puff durations (using bell- and square-shaped puffs). "Real-world" topography data collected from 10 participants during 1 week of at-home vaping were also analyzed. Recording anomalies and limitations of the devices, such as accuracy of detection of the puff end, flow rate dropouts, unreported puffs, and abandoned vaping sessions for the CReSS, and multi-peak puffs for the SPA-M were defined.ResultsThe accuracy of puff volumes and durations was determined for both devices. The error for SPA-M was generally within ±10%, whereas that for the CReSS varied more widely. The CReSS consistently underestimated puff duration at higher flow rates.ConclusionsCReSS and SPA-M topography devices can be used for real-world e-cigarette topography measurements, but researchers have to be aware of the limitations. Both devices can provide accurate measurements only under certain puff parameter ranges. The SPA-M provided more accurate measurements under a wider range of puffing parameters than the CReSS. Summary data reported by both devices require thorough analysis of the raw data to avoid misleading data interpretation.ImplicationsResults of this study provide researchers with valuable information about the capability of commercially available cigarette topography devices to measure real-world vaping behaviors. The differing measurement ranges of the two devices and puff recording limitations and anomalies should be taken into account during analysis and interpretation of real-world data.

Dataset Information

Mechanical behavior of fully expanded commercially available endovascular coronary stents.

Publications

Mechanical behavior of fully expanded commercially available endovascular coronary stents.

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