Ontology highlight
ABSTRACT:
SUBMITTER: Setty Y
PROVIDER: S-EPMC3231771 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Setty Yaki Y Dalfó Diana D Korta Dorota Z DZ Hubbard E Jane Albert EJ Kugler Hillel H
Development (Cambridge, England) 20120101 1
The proper renewal and maintenance of tissues by stem cell populations is simultaneously influenced by anatomical constraints, cell proliferation dynamics and cell fate specification. However, their relative influence is difficult to examine in vivo. To address this difficulty we built, as a test case, a cell-centered state-based computational model of key behaviors that govern germline development in C. elegans, and used it to drive simulations of cell population dynamics under a variety of per ...[more]