Ontology highlight
ABSTRACT:
SUBMITTER: Yang W
PROVIDER: S-EPMC3232115 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Yang W W Harris M A MA Cui Y Y Mishina Y Y Harris S E SE Gluhak-Heinrich J J
Journal of dental research 20111007 1
Using the Bmp2 floxed/3.6Col1a1-Cre (Bmp2-cKO(od)) mouse model, we have observed severe defects in odontogenesis and dentin formation with the removal of the Bmp2 gene in early-polarizing odontoblasts. The odontoblasts in the Bmp2-cKO(od) do not mature properly and fail to form proper dentin with normal dentinal tubules and activate terminal differentiation, as reflected by decreased Osterix, Col1a1, and Dspp expression. There is less dentin, and the dentin is hypomineralized and patchy. We also ...[more]