Ontology highlight
ABSTRACT:
SUBMITTER: Okumura R
PROVIDER: S-EPMC3232789 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20110919 12
Plasmid-carried qnrS1 is derived from Vibrio splendidus chromosomal qnrVS1. qnrVS1 transcripts increased 21- to 34-fold with subinhibitory concentrations of ciprofloxacin but much less with mitomycin. No LexA binding sites were upstream of qnrS1 or qnrVS1, and similar induction levels were observed in lexA-positive and lexA-negative Escherichia coli strains with native qnrS1 plasmid pMG306 but not with pUC18-cloned qnrS1 or qnrVS1. Thus, qnrS1 induction by quinolones is independent of the SOS sy ...[more]