Ontology highlight
ABSTRACT:
SUBMITTER: Rowland AF
PROVIDER: S-EPMC3232915 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Rowland Alexander F AF Larance Mark M Hughes William E WE James David E DE
Molecular and cellular biology 20111003 23
Insulin exerts many of its metabolic actions via the canonical phosphatidylinositide 3 kinase (PI3K)/Akt pathway, leading to phosphorylation and 14-3-3 binding of key metabolic targets. We previously identified a GTPase-activating protein (GAP) for Rac1 called RhoGAP22 as an insulin-responsive 14-3-3 binding protein. Insulin increased 14-3-3 binding to RhoGAP22 fourfold, and this effect was PI3K dependent. We identified two insulin-responsive 14-3-3 binding sites (pSer(16) and pSer(395)) within ...[more]