Ontology highlight
ABSTRACT:
SUBMITTER: March HN
PROVIDER: S-EPMC3233530 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
March H Nikki HN Rust Alistair G AG Wright Nicholas A NA ten Hoeve Jelle J de Ridder Jeroen J Eldridge Matthew M van der Weyden Louise L Berns Anton A Gadiot Jules J Uren Anthony A Kemp Richard R Arends Mark J MJ Wessels Lodewyk F A LF Winton Douglas J DJ Adams David J DJ
Nature genetics 20111106 12
The evolution of colorectal cancer suggests the involvement of many genes. To identify new drivers of intestinal cancer, we performed insertional mutagenesis using the Sleeping Beauty transposon system in mice carrying germline or somatic Apc mutations. By analyzing common insertion sites (CISs) isolated from 446 tumors, we identified many hundreds of candidate cancer drivers. Comparison to human data sets suggested that 234 CIS-targeted genes are also dysregulated in human colorectal cancers. I ...[more]