Ontology highlight
ABSTRACT:
SUBMITTER: Wakabayashi N
PROVIDER: S-EPMC3234649 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Wakabayashi Naoko N Tsujino Megumu M Tajiri Masaki M Taki Midori M Koshino Ayumi A Ikeda Hiroko H Fukushima Nobuyuki N Tsujiuchi Toshifumi T
Journal of toxicologic pathology 20100301 1
Lysophosphatidic acid (LPA) is a bioactive phospholipid that stimulates cell proliferation and migration, and protects cells from apoptosis. It interacts with specific G protein-coupled transmembrane receptors. Recently, frequent mutations of the LPA receptor-1 (LPA1) gene were detected in rat lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine (BHP). In this study, to evaluate the involvement of other LPA receptor gene alterations during lung carcinogenesis, we investigated mutat ...[more]