Ontology highlight
ABSTRACT:
SUBMITTER: Tang H
PROVIDER: S-EPMC3234743 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Tang Hongzhi H Yao Yuxiang Y Zhang Dake D Meng Xiangzhou X Wang Lijuan L Yu Hao H Ma Lanying L Xu Ping P
The Journal of biological chemistry 20110923 45
Nicotine, the main alkaloid produced by Nicotiana tabacum and other Solanaceae, is very toxic and may be a leading toxicant causing preventable disease and death, with the rise in global tobacco consumption. Several different microbial pathways of nicotine metabolism have been reported: Arthrobacter uses the pyridine pathway, and Pseudomonas, like mammals, uses the pyrrolidine pathway. We identified and characterized a novel 6-hydroxy-3-succinoyl-pyridine (HSP) hydroxylase (HspB) using enzyme pu ...[more]