Ontology highlight
ABSTRACT:
SUBMITTER: Valdes JL
PROVIDER: S-EPMC3234764 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Valdes Julie L JL Tang Jingrong J McDermott Mark I MI Kuo Jean-Cheng JC Zimmerman Seth P SP Wincovitch Stephen M SM Waterman Clare M CM Milgram Sharon L SL Playford Martin P MP
The Journal of biological chemistry 20110918 45
Sorting nexin 27 (SNX27) is a 62-kDa protein localized to early endosomes and known to regulate the intracellular trafficking of ion channels and receptors. In addition to a PX domain, SNX27 is the only sorting family member that contains a PDZ domain. To identify novel SNX27-PDZ binding partners, we performed a proteomic screen in mouse principal kidney cortical collecting duct cells using a GST-SNX27 fusion construct as bait. We found that β-Pix (p21-activated kinase-interactive exchange facto ...[more]