Ontology highlight
ABSTRACT:
SUBMITTER: Gadd MS
PROVIDER: S-EPMC3234805 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Gadd Morgan S MS Bhati Mugdha M Jeffries Cy M CM Langley David B DB Trewhella Jill J Guss J Mitchell JM Matthews Jacqueline M JM
The Journal of biological chemistry 20111024 50
Combinations of LIM homeodomain proteins form a transcriptional "LIM code" to direct the specification of neural cell types. Two paralogous pairs of LIM homeodomain proteins, LIM homeobox protein 3/4 (Lhx3/Lhx4) and Islet-1/2 (Isl1/Isl2), are expressed in developing ventral motor neurons. Lhx3 and Isl1 interact within a well characterized transcriptional complex that triggers motor neuron development, but it was not known whether Lhx4 and Isl2 could participate in equivalent complexes. We have i ...[more]