Ontology highlight
ABSTRACT:
SUBMITTER: Nomme J
PROVIDER: S-EPMC3234847 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Nomme Julian J Fanning Alan S AS Caffrey Michael M Lye Ming F MF Anderson James M JM Lavie Arnon A
The Journal of biological chemistry 20111026 50
Tight junctions are cell-cell contacts that regulate the paracellular flux of solutes and prevent pathogen entry across cell layers. The assembly and permeability of this barrier are dependent on the zonula occludens (ZO) membrane-associated guanylate kinase (MAGUK) proteins ZO-1, -2, and -3. MAGUK proteins are characterized by a core motif of protein-binding domains that include a PDZ domain, a Src homology 3 (SH3) domain, and a region of homology to guanylate kinase (GUK); the structure of thi ...[more]