Ontology highlight
ABSTRACT:
SUBMITTER: Rosenberg MF
PROVIDER: S-EPMC3234965 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Rosenberg Mark F MF O'Ryan Liam P LP Hughes Guy G Zhao Zhefeng Z Aleksandrov Luba A LA Riordan John R JR Ford Robert C RC
The Journal of biological chemistry 20110919 49
Cystic fibrosis affects about 1 in 2500 live births and involves loss of transmembrane chloride flux due to a lack of a membrane protein channel termed the cystic fibrosis transmembrane conductance regulator (CFTR). We have studied CFTR structure by electron crystallography. The data were compared with existing structures of other ATP-binding cassette transporters. The protein was crystallized in the outward facing state and resembled the well characterized Sav1866 transporter. We identified reg ...[more]