Ontology highlight
ABSTRACT:
SUBMITTER: Maximov A
PROVIDER: S-EPMC3235366 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Maximov Anton A Tang Jiong J Yang Xiaofei X Pang Zhiping P ZP Südhof Thomas C TC
Science (New York, N.Y.) 20090101 5913
Trans-SNAP receptor (SNARE, where SNAP is defined as soluble NSF attachment protein, and NSF is defined as N-ethylmaleimide-sensitive factor) complexes catalyze synaptic vesicle fusion and bind complexin, but the function of complexin binding to SNARE complexes remains unclear. Here we show that in neuronal synapses, complexin simultaneously suppressed spontaneous fusion and activated fast calcium ion-evoked fusion. The dual function of complexin required SNARE binding and also involved distinct ...[more]