Ontology highlight
ABSTRACT:
SUBMITTER: Matsuura BS
PROVIDER: S-EPMC3235802 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Matsuura Bryan S BS Condie Allison G AG McBee Ian A IA Buff Ryan C RC Karahalis Gregory J GJ Stephenson Corey R J CR
Organic letters 20111109 23
An intramolecular cyclization cascade reaction has been developed utilizing a high valent palladium intermediate that generates a carbon-carbon and carbon-oxygen bond in a single transformation. This method provides rapid access to highly functionalized tricyclic scaffolds, including spirocyclic cyclohexadienones. Good yields and mild conditions are reported with high tolerance toward oxygen and water. ...[more]