Unknown

Dataset Information

0

Intercepting Wacker intermediates with arenes: C-H functionalization and dearomatization.


ABSTRACT: An intramolecular cyclization cascade reaction has been developed utilizing a high valent palladium intermediate that generates a carbon-carbon and carbon-oxygen bond in a single transformation. This method provides rapid access to highly functionalized tricyclic scaffolds, including spirocyclic cyclohexadienones. Good yields and mild conditions are reported with high tolerance toward oxygen and water.

SUBMITTER: Matsuura BS 

PROVIDER: S-EPMC3235802 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

altmetric image

Publications

Intercepting Wacker intermediates with arenes: C-H functionalization and dearomatization.

Matsuura Bryan S BS   Condie Allison G AG   McBee Ian A IA   Buff Ryan C RC   Karahalis Gregory J GJ   Stephenson Corey R J CR  

Organic letters 20111109 23


An intramolecular cyclization cascade reaction has been developed utilizing a high valent palladium intermediate that generates a carbon-carbon and carbon-oxygen bond in a single transformation. This method provides rapid access to highly functionalized tricyclic scaffolds, including spirocyclic cyclohexadienones. Good yields and mild conditions are reported with high tolerance toward oxygen and water. ...[more]

Similar Datasets

| S-EPMC8346228 | biostudies-literature
| S-EPMC4832838 | biostudies-other
| S-EPMC5716473 | biostudies-literature
| S-EPMC5726549 | biostudies-literature
| S-EPMC6558637 | biostudies-literature
| S-EPMC5089574 | biostudies-literature
| S-EPMC7496267 | biostudies-literature
| S-EPMC9355940 | biostudies-literature
| S-EPMC4501312 | biostudies-literature
| S-EPMC7810233 | biostudies-literature