Ontology highlight
ABSTRACT:
SUBMITTER: Cui X
PROVIDER: S-EPMC3236503 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Cui Xiaohong X Adler Stuart P SP Davison Andrew J AJ Smith Larry L Habib El-Sayed E el-SE McVoy Michael A MA
Journal of biomedicine & biotechnology 20111130
Bacterial artificial chromosome (BAC) clones have proven invaluable for genetic manipulation of herpesvirus genomes. BAC cloning can also be useful for capturing representative genomes that comprise a viral stock or mixture. The Towne live attenuated cytomegalovirus vaccine was developed in the 1970s by serial passage in cultured fibroblasts. Although its safety, immunogenicity, and efficacy have been evaluated in nearly a thousand human subjects, the vaccine itself has been little studied. Inst ...[more]